CORDIS Project
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This project explores the role of USF transcription factors in skin response to UV radiation and melanoma progression. It aims to identify target genes and understand the molecular mechanisms that protect skin and influence cancer development.
The skin is the first body defence towards various injuries including UV-rays.
The molecular mechanism underlying the UV-response is in part dependant on gene expression modulation implicating the ubiquitous family of USF transcription factors.
They have been largely involved as critical UV-activators of genes expression in melanocytes, mediating the UV-induced tanning-response following activation of the stress-responsive p38 kinase.
Mitf, the master melanocyte regulator, mediating melanocyte s…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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