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uPROPHET aims to develop urinary proteomic profiling as a non-invasive tool for selecting heart failure patients for transplantation and monitoring graft performance post-transplant. This innovative approach seeks to improve patient outcomes by providing personalized risk stratification and enhancing immunosuppression…
The proof of concept underlying uPROPHET rests on the EPLORE findings that capillary electrophoresis coupled with high-resolution mass-spectroscopy reproducibly identified unique urinary proteomic (UP) signatures associated with subclinical left ventricular dysfunction, renal impairment and adverse cardiovascular outcomes.
Consensus criteria currently applied for the selection of patients for heart transplantation (HTx) leave an inconvenient margin of uncertainty, because of the unpredictable co…
KATHOLIEKE UNIVERSITEIT LEUVEN
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