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The Upbiosens project develops a method to create stable DNA-capped upconversion nanoparticles for detecting specific RNA or DNA sequences. This technology uses near-infrared light to enable sensitive and selective biosensing, with potential applications in diagnostics and gene therapy.
The Upbiosens project describes a novel method to produce water-dispersible and stable DNA-capped upconversion nanoparticles (UCNPs), keeping intact (or enhancing) the properties of both DNA and UCNPs.
The UCNP@DNA nanohybrid will be able to detect the complementary target miRNA or DNA sequence.
This detection will be based on the UCNP emission changes after NIR excitation in the presence of the fluorophore target RNA/DNA sequence.
The hybridization will enable FRET from the UCNP to the fluoroph…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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