CORDIS Project
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This project investigates the evolution of balanced lethal systems, where two chromosome forms with distinct lethal alleles are necessary for survival. By studying the genetic architecture of newts, the research aims to explain how these systems arise and persist, challenging traditional evolutionary theories.
Natural selection is supposed to keep lethal alleles (dysfunctional or deleted copies of crucial genes) in check.
Yet, in a balanced lethal system the frequency of lethal alleles is inflated.
Because two forms of a chromosome carry distinct lethal alleles that are reciprocally compensated for by functional genes on the alternate chromosome form, both chromosome forms – and in effect their linked lethal alleles – are required for survival.
The inability of natural selection to purge balanced leth…
UNIVERSITEIT LEIDEN
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