CORDIS Project
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This project investigates the role of the transcription factor ID3 in liver macrophages, known as Kupffer cells, to understand how they interact with hepatocytes. It employs advanced genetic screening techniques to identify the signals that regulate ID3 expression and the functional implications of these interactions f…
Macrophages perform unique tissue-specific functions that are essential for the homeostasis of each organ.
To perform these tissue-specific functions, each resident macrophage expresses a relatively unique gene expression profile controlled by specific transcription factors.
Kupffer cells (KCs) are the biggest macrophage population of the body and represent 10% of all liver cells.
The Guilliams lab recently reported that each KC projects an important part of its body across the liver endothelial…
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