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The UnMiss project investigates the genetic basis of phenotypic diversity using yeast as a model organism. By developing a genetic variant atlas and analyzing traits across natural isolates, it aims to uncover the sources of missing heritability in complex traits.
Understanding the genetic causes of phenotypic diversity in natural populations is a major challenge.
While advances have been made in identifying the genetic basis of complex traits, our knowledge remains incomplete.
Whole-genome sequencing has enabled genome-wide association studies (GWAS) to link genetic variants to traits, including human diseases.
However, even with thousands of causal variants identified, they often account for only a small fraction of phenotypic variation.
Uncovering the…
UNIVERSITE DE STRASBOURG
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