CORDIS Project
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This project investigates the mechanisms of liver metastasis in colorectal cancer, focusing on tumor vessel co-option. It aims to inhibit Wnt signaling to enhance the effectiveness of standard anti-angiogenic therapy using patient-derived organoids and advanced imaging techniques.
An estimated 25-50% of colorectal cancer patients will encounter liver metastasis during their illness.
Tumor vessel co-option is a non-angiogenic mechanism whereby tumors, rather than forming new blood vessels (a process known as angiogenic growth), hijack pre-existing blood vessels in the affected organ.
Standard anti-angiogenic therapy (AAT) is ineffective against vessel co-optioned tumors.
This process has been linked to unfavorable patient outcomes.
The exact mechanisms distinguishing vesse…
AARHUS UNIVERSITET
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