CORDIS Project
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The project investigates a new model of influenza evolution called 'antigenic thrift,' which could lead to more effective vaccines. By targeting specific epitopes, it aims to create a vaccine that provides long-lasting immunity without the need for annual vaccinations.
The antigenic evolution of influenza is conventionally assumed to occur by ‘antigenic drift’ where new strains arise through the incremental addition of mutations in surface glycoproteins.
However, the antigenic drift model can only explain the epidemiology and limited genetic diversity observed among influenza virus populations by imposing constraints on the mode and tempo of mutation.
We have shown that an alternative model known as ‘antigenic thrift’ successfully models the epidemiology and g…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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