CORDIS Project
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This project investigates the role of phosphatidylserine on viable sperm and its receptors on oocytes in mammalian fertilization. By exploring these molecular interactions, the research aims to uncover new factors influencing reproductive health and fertility.
Fertilization is essential for a species to survive.
Mammalian sexual reproduction requires the fusion between the haploid gametes sperm and egg to create a new diploid organism.
Although fertilization has been studied for decades, and despite the remarkable recent discoveries of Izumo (on sperm) and Juno (on oocytes) as a critical ligand:receptor pair, due to the structure of Izumo and Juno, it is clear that other players on both the sperm and the oocytes must be involved.
While the focus of o…
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