CORDIS Project
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This project studies how the enzyme ADAR1 interferes with RNA interference pathways in mammalian cells. It aims to understand the mechanisms of ADAR1's action by examining its interactions with RNAi components using various advanced techniques.
The most common form of editing in mammalian RNA is deamination of adenosine to inosine by ADAR1 and ADAR2. ADAR1p150, an interferon inducible adenosine deaminase, is also known to antagonize RNA interference (RNAi).
To date, the mechanism by which this is carried out is unclear.
For example, it is unknown if the embryonic lethality of ADAR1 knockout mice is related to antagonism of RNAi.
Thus, I propose to study how ADAR1 antagonizes the RNAi pathway and if it interacts directly with RNAi compo…
MEDICAL RESEARCH COUNCIL
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