CORDIS Project
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This project explores how abnormal behavior of B cells contributes to the production of HIV neutralizing antibodies. It aims to understand the cellular processes involved in antibody development during HIV infection, which could inform vaccine strategies for various pathogens.
I will establish how abnormal B cell behaviour contributes to the generation of HIV neutralising antibodies by studying B cell biology:
Previous studies show that broadly neutralising HIV antibodies are the most highly-mutated human antibodies ever isolated, with unusually long binding loops and polyreactivity, suggestive of changes to B cell tolerance and germinal centre selection mechanisms.
These remarkable antibodies develop only during HIV infection, concurrent with immune dysfunction, not…
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