CORDIS Project
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This project investigates how immune cells cross the Blood-Cerebrospinal Fluid barrier, challenging the notion of the brain as an immune-privileged organ. It aims to understand the mechanisms of immune trafficking and its implications for brain diseases.
Immune cells continuously traverse our body, crossing vascular and epithelial barriers; from lymphatic organs into the blood, and from the blood into various tissues for surveillance or to fight infection.
However, the brain has long been considered an immune-privileged organ.
Barriers protecting the brain against infection or harmful toxic agents were also thought to block entry of immune cells, leaving immune functions to brain-resident microglia cells.
This dogma was recently overturned when…
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