CORDIS Project
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The project focuses on improving outcomes for myeloid malignancies by developing advanced diagnostic tools and targeted therapies. It aims to utilize single-cell RNA sequencing to analyze hematopoietic stem and progenitor cells, explore the effects of preleukemic mutations, and identify drugs that can target these muta…
As humans age, Hematopoietic Stem and Progenitor Cells (HSPCs) accumulate preleukemic mutations (pLMs), forming preleukemic HSPCs (preL-HSPCs) and leading to clonal hematopoiesis (CH).
While the link between CH and myeloid malignancies is established, predicting progression remains elusive.
The Shlush lab aims to enhance myeloid malignancies outcomes through early diagnosis and treatment.
Still, it faces three gaps: 1) lacking advanced tools for diagnosis/risk stratification beyond mutations, 2)…
WEIZMANN INSTITUTE OF SCIENCE
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