CORDIS Project
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This project aims to explore the specificity of the ubiquitin system by studying atypical ubiquitin chains and their cellular roles. It seeks to identify the machinery involved in their assembly and the proteins that interact with these chains, enhancing our understanding of cellular regulation.
Protein ubiquitination is an important posttranslational modification that regulates virtually all cellular processes.
Its versatility arises from the ability of ubiquitin to form eight structurally and functionally distinct polymeric chains.
It is clear that all chain types exist in cells.
The two chain types that have been studied in detail have distinct, non-overlapping cellular functions. A lack of tools has hindered progress to define roles of the remaining ‘atypical’ ubiquitin chains.The o…
MEDICAL RESEARCH COUNCIL
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