CORDIS Project
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This project focuses on the process of ubiquitination, a key post-translational modification that regulates protein function. It aims to elucidate the mechanisms of ubiquitin attachment to proteins, which is crucial for understanding various diseases, including cancer.
The attachment of Ubiquitin (Ub) to proteins (ubiquitination) is one of the most abundant post‐translational modifications in eukaryotes.
Deregulation of the ubiquitination reaction is the cause of various diseases, including cancer.
Ubiquitination is catalyzed by the sequential action of an activating (E1), a conjugating (E2), and a ligating (E3) enzyme.
Ubiquitination enzymes contain catalytic cysteine residues that transfer Ub via thioester intermediates to a substrate lysine residue.
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