CORDIS Project
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This project focuses on understanding the mechanisms that ensure accurate DNA replication and how their disruption can lead to cancer. It aims to identify regulatory factors involved in DNA replication stress using advanced microscopy and genetic techniques, potentially revealing new cancer treatment strategies.
Accurate DNA replication is an essential prerequisite of genome stability, and nature has evolved numerous mechanisms to ensure precise and complete genome duplication.
Subversion of these protective mechanism results in genome instability, the hallmark of cancer and many human developmental syndromes.
Paradoxically, recent evidence suggests that pharmacological interference with these mechanisms represents a promising therapeutic strategy, because cancer cells show a pronounced dependency on th…
KOBENHAVNS UNIVERSITET
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