CORDIS Project
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This project aims to enhance cancer treatment by targeting the immune checkpoint B7H3, which is often upregulated in tumors. By exploring its interactions with T cells and the ubiquitin system, the research seeks to improve immune responses against cancer.
Immunotherapies have revolutionized the treatment of multiple cancer types in the last decade.
Nonetheless, non-small cell lung cancer and triple-negative breast cancer exhibit only restricted response to immune checkpoint blockade.
Especially in advanced tumor stages, clinical options are limited and novel approaches to enhance anti-tumor immune responses are needed.
The immune checkpoint family member B7H3 (PD-L3) is frequently upregulated in cancer cells.
Studies have shown that B7H3 promotes…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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