CORDIS Project
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This project explores the regulation of microtubule-associated proteins, which are crucial for cellular processes like chromosome segregation. It focuses on understanding how these proteins are controlled by a specific ubiquitin E3 ligase, potentially leading to new therapeutic strategies for related diseases.
The microtubule cytoskeleton is a dynamic array of cylindrical polymers that play important roles in various cellular processes including chromosome segregation and ciliogenesis.
Hundreds of accessory factors – grouped under the term microtubule-associated proteins (MAPs) – orchestrate this network by governing the interaction profile and growth behaviour of microtubules.
Due to this critical function, the precise abundance and distribution of MAPs within cells is of high importance and their de…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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