CORDIS Project
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This project explores the role of the ubiquitin-proteasome system in Alzheimer's disease, focusing on how it affects the Golgi apparatus in neurons. By identifying regulatory mechanisms, it aims to uncover new therapeutic targets for neurodegeneration.
Alzheimer’s disease (AD) is the most common neurodegenerative disorder which affects 47 million patients worldwide.
However, the underlying molecular mechanisms leading to sporadic-AD remain unknown and preventive treatment is not yet available.
Lately, the ubiquitin-proteasome system has been implicated in AD.
Dr.
Merbl’s laboratory recently discovered a novel mechanism of Golgi-localized proteasomal degradation that controls Golgi integrity under stress.
As the Golgi apparatus is the major hub…
WEIZMANN INSTITUTE OF SCIENCE
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