CORDIS Project
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This project develops advanced tools for studying polyubiquitination, a key protein modification affecting cellular functions. By creating custom enzymes for specific ubiquitin linkages, it aims to explore their roles in genome maintenance and responses to DNA damage, with implications for cancer and aging research.
Ubiquitylation is an essential posttranslational modification that governs the activities and interactions of cellular proteins.
The structural diversity of polyubiquitin chains, collectively called the ubiquitin code, is thought to determine the fate of the modified proteins.
Although many analytical and inhibitory ubiquitin-specific reagents exist, we lack the tools to create polyubiquitin chains of defined linkage on a protein of interest in cells to investigate their signalling functions.
We…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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