CORDIS Project
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This project focuses on understanding the anaphase promoting complex, which regulates cell division by targeting proteins for degradation. It aims to clarify how substrate-binding partners disengage during this process, contributing to genome stability and potential drug development.
The anaphase promoting complex/ cyclosome (APC/C) is an E3 ubiquitin ligase that controls the cell division cycle by targeting main cell cycle regulators for proteasomal degradation, thereby ensuring error-free cell division and safeguarding genome stability.
Its foremost activity is during cell division, or mitosis, when two sets of sister chromatids are equally divided over two newly formed daughter cells.Intriguingly, APC/C substrates that are degraded at the metaphase-to-anaphase transition…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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