CORDIS Project
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This project explores the role of ubiquitin signaling in neurodegenerative diseases, particularly Alzheimer's disease. It aims to understand how disruptions in this signaling pathway contribute to disease progression and to identify potential neuroprotective mechanisms.
Neurodegenerative diseases share similar hallmarks such as protein aggregation, suggesting that impaired protein degradation may be a common denominator.
The major cellular pathways mediating protein degradation are the Ubiquitin-proteasome system (UPS) and autophagy, both regulated by ubiquitin signaling.
However, aside from specific mutations in familial neurodegeneration cases, an early cause for failing ubiquitin-dependent proteolysis remains unclear.
This proposal will test our unconvention…
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