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The UbADPrLINK project investigates the role of the enzyme PARP14 in regulating adenosine diphosphate-ribosylation, a key cellular response to DNA damage and viral infections. By exploring the interactions between PARP14 and other proteins, the project aims to enhance understanding of cellular signaling and develop pot…
Intricate networks of post-translational modifications (PTMs) shape how cells respond to environmental threats.
Adenosine diphosphate (ADP)-ribosylation (ADPr) has emerged as a pivotal PTM elicited by DNA damage or host immune responses to combat viruses, including SARS-CoV-2.
This protective ADPr signature can be regulated by PARP14, a versatile enzyme that can both install and remove ADPr.
While the connection between ADPr signalling and these damaging events is clear, the physiological target…
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