CORDIS Project
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This project investigates the role of ubiquitin chain linkages in tumor necrosis factor (TNF) signaling, focusing on their impact on immunity and inflammation-related cancer. By analyzing these linkages within the TNF receptor signaling complex, the research aims to elucidate the molecular mechanisms underlying TNF's f…
Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer.
Signalling processes mediated by ubiquitin are crucial for TNF signalling.
The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains.
Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkage types in the native TNF receptor signalling complex (TNF-RSC).
Our knowledge of the specific funct…
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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