CORDIS Project
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The U-KARE project aims to understand the interactions between the pathogen Klebsiella pneumoniae and the human immune system. By exploring how this bacterium manipulates host defenses, the research seeks to identify new therapeutic strategies against antibiotic-resistant infections.
Pneumonia is leading cause of death from infection.
During infection, microbial presence is monitored by receptors recognizing evolutionary conserved structures.
Pathogen recognition is associated with the activation of few regulators and signaling pathways controlling host defence systems. A better understanding of the host-pathogen interaction offers the potential for pharmacological intervention by targeting the host side.U-KARE aims to gain a holistic understanding of the networks conveying…
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