CORDIS Project
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This project investigates transcriptional memory in yeast, focusing on how cells adapt to repeated stimuli. It employs advanced imaging and genetic techniques to understand the molecular mechanisms behind memory inheritance and its impact on cell survival.
Transcriptional memory offers a mechanism for adaptive response to various types of repeated stimuli.
Thus far the mechanisms that govern transcriptional memory are poorly understood, although evidence of its heritability to progeny suggests that they rely on epigenetic cues mediated through chromatin.
Furthermore the dynamics of transcriptional memory at the single-cell level are not known, which is key to understanding the regulation of transcriptional dynamics and environmental adaptation.
Th…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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