CORDIS Project
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This project examines the role of a specific enzyme, phosphoinositol-3-kinase delta, in the activation of T cells during immune responses. It uses advanced imaging techniques to study T cell interactions in live mice, aiming to enhance understanding of immune regulation.
The adaptive immune system protects us from nocuous microbes, yet excessive immune reactions can lead to the development of autoimmunity.
The initiation of adaptive immune responses takes place in lymphoid organs, including peripheral lymph nodes (PLN).
Inside PLN, T cells become activated through the molecular interactions of the T cell receptor with cognate peptide-MHC (pMHC) molecules and costimulatory molecules on dendritic cells (DC). TCR-mediated signals lead to the activation of the phosp…
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