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The TUMORLY project aims to develop a novel spatial method for analyzing tumor specimens at a single-cell level. This approach will help understand the role of chromosome Y loss in male cancer development, providing insights into disease mechanisms and potentially improving patient outcomes.
Results from my ERC funded DIALOY and HEARTLY projects establish that during-life acquired loss of chromosome Y (LOY) in blood cells contribute to all major causes of male deaths, incl. various types of cancer, Alzheimer’s disease and cardiovascular disease.
Recent single cell analyses identify LOY-cells in the blood of all studied men and in many other tissues, suggesting that LOY might be an inevitable result of living.
How LOY in blood contributes to increased risk for diseases manifesting in…
UPPSALA UNIVERSITET
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