CORDIS Project
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This project investigates the structural and dynamic mechanisms of G-protein coupled receptors (GPCRs) using rhodopsin as a model. It aims to understand how receptor conformational changes facilitate signal transduction, which could enhance drug development targeting these receptors.
Upon binding an agonist, the seven transmembrane (TM) helical bundle of a G-protein coupled receptor (GPCR) undergoes conformational changes that catalyze nucleotide exchange within bound G proteins.
In rhodopsin, the agonist arises from light-induced isomerization of the retinal ligand, but an active conformation (Ops*) can also be adopted by the opsin apoprotein.
We recently solved the structure of Ops* in complex with a peptide from the C-terminal ±-5 helix of the G protein.
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