CORDIS Project
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The Trxn-PURGE project aims to identify and activate latent HIV within memory T cells, which remain unaffected by current therapies. By employing innovative strategies in genetics and biochemistry, it seeks to uncover new molecular targets for HIV eradication.
The persistence of a transcriptionally competent but latent HIV infected memory CD4+T cell reservoir, despite the effectiveness of Highly Active Antiretroviral therapy (HAART) against active virus, presents the main impediment to HIV eradication. A novel concept in HIV eradication is to activate latent virus to subsequently eliminate with HAART.
Much effort has gone into identification of protein complexes that regulate HIV LTR activity.
Strategies have mainly relied on candidate approaches.
How…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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