CORDIS Project
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This project investigates the role of the glucose-dependent insulinotropic polypeptide receptor in regulating energy and glucose metabolism. By examining how co-agonists and antagonists of this receptor affect obesity and type-2 diabetes, the research aims to uncover mechanisms that could lead to new obesity treatments…
Obesity is a major health threat, but efficient pharmacotherapies are yet not available.
First demonstrated by us to decrease body weight and hyperglycemia in obese mice, unimolecular co-agonists at the receptors for glucagon-like peptide-1 (GLP-1) and the glucose-dependent insulinotropic polypeptide (GIP) efficiently corrected obesity and type-2 diabetes in recent phase 3 clinical trials.
While GLP-1R/GIPR co-agonists are safe and effective, GIP regulation of metabolism remains enigmatic, with…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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