CORDIS Project
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This project investigates the role of the TRPV2 calcium channel in macrophages, focusing on its activation and physiological functions in immune responses. It aims to uncover the signaling pathways that regulate this channel's activity.
Macrophages are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens.
However, they are also involved in various inflammatory pathologies.
Membrane receptors of chemokines control many aspects of macrophages functions by stimulating various 2nd messenger systems, important amongst these are PI3Ks and Ca2+.
However the identity of the Ca2+ channels involved in Ca2+ influx and the cellular responses regulati…
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