CORDIS Project
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This project develops RNA-based sensors for real-time imaging of lipid molecules in leukocytes. It aims to enhance understanding of signaling processes during immune responses and could have broader applications in cell biology.
Modulation of leukocyte adhesiveness is critical to leukocyte function during the immune response.
In order to extravasate from the blood stream, leukocyte rolling must be followed by integrin-mediated rapid arrest.
Intergins play a crucial role on chemokine-induced arrest of leukocytes on blood vessels.
Signaling events mediating adhesion are extensively studied.
Increasing evidence underlays the essential role of lipid second messenger as important fine regulators of signaling cascade leading…
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