CORDIS Project
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This project develops a novel method called Nano-tRNAseq to accurately measure transfer RNA abundances and modifications, aiming to utilize them as biomarkers for cancer detection and progression. By leveraging advanced sequencing technologies and deep learning, it seeks to provide a cost-effective solution for analyzi…
Transfer RNAs (tRNAs) are abundant, heavily-modified small non-coding RNAs that play a pivotal role in decoding genetic information, determining which transcripts are highly and poorly translated at a given moment.
Dysregulation of tRNA abundances and tRNA modifications is a well-known feature in cancer cells, leading to enhanced translation of specific oncogenic proteins.
Despite the well-established association between tRNA dysregulation and cancer progression and malignancy, tRNA abundances a…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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