CORDIS Project
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This project investigates the role of transfer RNA (tRNA) availability in gene expression regulation. Using yeast as a model, it aims to map tRNA dynamics and their impact on protein translation and cellular fitness under various conditions.
Regulation of gene expression is a fundamental process in all cellular systems.
While the major steps in gene regulation such as transcription and translation are well understood, the role of tRNA availability (e.g. abundance, half-life) in regulating translation is largely unknown.
The ultimate objective of this proposal is to investigate how tRNA availability within a cell can influence which mRNA molecules are actively translated by the ribosome.
More specifically, it aims to address (i) whet…
MEDICAL RESEARCH COUNCIL
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