CORDIS Project
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This project investigates the molecular mechanisms of TRIM E3 ligases, focusing on TRIM25, which plays a crucial role in cellular processes. The research aims to elucidate how TRIM25 interacts with substrates and its dual activity for ubiquitin and ISG15, contributing to understanding disease mechanisms.
Ubiquitin E3 enzymes participate in the last step of a three-enzyme cascade, where they transfer ubiquitin from E2 enzymes to substrates, therefore are responsible to bring the right substrate to the right E2 enzyme.
The tripartite motif (TRIM) family of ubiquitin E3 ligases includes 70 members that are involved in cellular processes such as immune signaling, transcriptional regulation and apoptosis.
Defects in TRIM E3 ligase activity have been linked to cancer and developmental and genetic dise…
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