CORDIS Project
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This project focuses on advancing T-cell receptor gene therapy for cancer treatment, specifically targeting acute myeloid leukemia. By combining expertise in T-cell biology and immune repertoire sequencing, the project aims to identify novel tumor-specific T-cell receptors to enhance the effectiveness of immunotherapy.
Recent encouraging clinical results obtained with engineered T lymphocytes and increasing advances in the genome editingfield, have opened new opportunities for T-cell receptor (TCR) gene therapy as an immunotherapeutic approach for cancer.Unfortunately, the broad applicability of this treatment is still hampered by the possible mispairing of exogenous/endogenousTCR chains and by the limited number of high avidity tumor-specific TCRs.
While the first issue has been successfullyaddressed by the h…
OSPEDALE SAN RAFFAELE SRL
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