CORDIS Project
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This project aims to discover new compounds that inhibit the enzyme trans-sialidase in Trypanosoma cruzi, the causative agent of Chagas’ disease. It employs high-throughput screening and computational modeling to design and evaluate potential drug candidates.
This proposal focus on finding new potential lead compounds to inhibit the trans-sialidase of Trypanosoma cruzi, as a step towards finding a drug against Chagas’ disease. A new high through-put enzyme assay will be used to scan a large library of small molecules and in combination with in silico pharmacophoric modelling this is expected to provide new types of scaffolds as well as identifying important functionalities in the ligand.
Based on the obtained information a set of ligands will be desi…
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