CORDIS Project
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This project explores the role of upstream open reading frames in cancer development. By analyzing their function and translation, it aims to uncover new mechanisms of gene expression regulation that could lead to innovative cancer diagnostics and therapies.
The control of translation is a key determinant of protein abundance, which in turn defines cellular states.
The impact of translational regulation may be even greater during the transition from homeostasis to malignancy, as revealed by the surprisingly low correlations between mRNA and protein levels in human cancer databases.
This raises the intriguing possibility that through an ability to generate aberrant downstream networks of translational regulators, oncogenic drivers might impose altere…
UNIVERSITAT ZURICH
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Switzerland, LAUSANNE
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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