CORDIS Project
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This project explores the role of the TFIIH protein complex in DNA repair and transcription regulation. It aims to understand how mutations in this complex contribute to genetic disorders and cancer, enhancing knowledge of genome integrity.
Understanding how the genetic information of a cell is retrieved but also protected from insults, is a major challenge facing modern molecular biology.
Indeed, one of the most important developments in human genetics over the last decade, has been the realization that diseases such as cancer but also ageing stem from some dis-regulation in the expression and preservation of the genetic information. TFIIH is a multiprotein complex that is essential in transcription and DNA repair.
Mutations in so…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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