CORDIS Project
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This project aims to identify the roles of membrane transporters in the Leishmania parasite, which causes neglected diseases. By using CRISPR-Cas9 to create mutant strains, it seeks to uncover mechanisms of infection and survival within host cells.
Leishmaniases are among the world's most neglected diseases.
It´s causative agent - Leishmania - is transmitted by the bite of a sand fly.
In the host, the parasite is taken up by macrophages and proliferates in the harsh conditions of the host phagolysosome.
Currently available drugs for treatment present major drawbacks, urging the need for more effective, safer, and cheaper drugs.
The molecular and cellular mechanisms that enable Leishmania to subvert macrophage defence mechanisms and cause d…
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