CORDIS Project
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This project investigates the mechanisms that maintain genome integrity during transcription, focusing on how DNA damage affects RNA polymerase II activity. It aims to understand the balance between transcription and DNA repair processes to prevent mutations and genome instability.
Maintaining genome integrity is crucial, especially in protein-encoding genes. DNA damage in genes can give rise to harmful mutations, but it can also directly obstruct the progress of transcribing RNA polymerase II (RNAPII), thereby blocking gene expression.
Not surprisingly, repair pathways have evolved that specifically target lesions that stop RNAPII during its journey across a gene, so-called transcription-coupled repair pathways.
As an alternative and ¿last resort¿, damage-stalled RNAPII c…
THE FRANCIS CRICK INSTITUTE LIMITED
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