CORDIS Project
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This project aims to identify sensory receptors involved in pain perception using a novel genetic screening method. By uncovering the mechanisms of how these receptors respond to harmful stimuli, the research seeks to discover new targets for pain relief therapies.
The perception of pain is crucial for our survival, enabling avoidance of harmful physical and chemical insults.
Pain initiates in primary sensory neurons, which are highly variable cells innervating the skin, mucus membranes and internal organs.
These neurons express combinations of receptor molecules decoding adverse mechanical, thermal and chemical stimuli.
Receptor molecules sensitive to these cues decode such inputs into action potentials, which are then relayed to the central nervous syste…
UNIVERSITY OF LEEDS
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