CORDIS Project
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This project aims to explore the process of meiotic exit in mammals by developing transgenic mouse models. It focuses on understanding the cellular changes that occur after fertilization, which are crucial for stem cell research and cancer mechanisms.
Fertilisation occurs when two highly specialised cells (sperm and egg) unite, causing an 'awakening' of the egg, known as meiotic exit.
During meiotic exit, a one-cell embryo (zygote) is formed that is totipotent - it can give rise to an entire individual.
Given the fundamental nature of this event, it is remarkable that almost nothing is known about the regulation of meiotic exit in mammals.
Ignorance about meiotic exit can and must be addressed; the mechanisms that underlie the period of meiot…
UNIVERSITY OF BATH
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