CORDIS Project
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This project investigates how proteins fold and assemble in yeast cells during protein synthesis. By using a new method called selective ribosome profiling, it aims to understand the role of chaperones and translation speed in the co-translational assembly of protein complexes.
Biological activity of cells depends on timely production of natively folded proteins by powerful translation and folding machineries.
At a critical regulatory intersection of translation and folding, ribosomes act as integration hubs coordinating chaperone, enzyme and membrane targeting factor activity, and mRNA coding sequence specifies local changes in translation speed, influencing folding.
Final assembly of proteins into oligomeric complexes however, has long been considered posttranslation…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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