CORDIS Project
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This project explores how certain peptide sequences can halt protein synthesis during translation. By using advanced techniques to study ribosome-nascent chain complexes, it aims to uncover the mechanisms behind this process and develop predictive algorithms for identifying regulatory peptide sequences.
Following initiation of protein synthesis, the nascent polypeptide must journey through the exit tunnel of the ribosome.
Although this has typically been deemed a passive process, it is established that certain peptide sequences interact with rRNA components and ribosomal proteins lining the walls of the tunnel to bring protein synthesis to a complete halt.
In many cases, translational arrest is dependent upon the presence of a small cofactor – such as an amino acid or an antibiotic – acting in…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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