CORDIS Project
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Trained_Lung investigates how bacterial pneumonia affects immune responses and inflammation in the lungs. The project aims to understand the mechanisms of trained immunity in macrophages and how this influences lung health, particularly in response to subsequent infections and pollutants.
The world health organisation has labeled inflammatory diseases the greatest threat to human health.
Inflammation is a major cause of pathogenesis in respiratory conditions such as bronchiectasis, ARDS, and COPD.
There is a growing appreciation that our prior pathogen exposure can induce trained immunity in macrophages.
Trained_Lung will explore how bacterial pneumonia induces central trained immunity and how this can lead to excessive inflammation and lung damage, in response to other bacteria…
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
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