CORDIS Project
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This project investigates how to enhance vaccination efficacy in the elderly by inducing 'trained immunity' in innate immune cells. It aims to understand the genetic and environmental factors affecting immune responses to improve vaccine design for older adults.
The host defense, especially the adaptive immunity, is defective in the elderly, with a dramatic drop for the efficacy of vaccination with old age.
Interestingly however, the innate immunity of older individuals is relatively intact, and we recently described that epigenetic and functional reprogramming of innate immune cells by certain vaccines and mild infections, termed ‘trained immunity’, induces potent heterologous protection against infections. I propose that induction of trained immunity…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
HELLENIC INSTITUTE FOR THE STUDY OF SEPSIS
Greece, ATHENS
Type: Research institute
Activity type: Research Organisations
SME: Yes
STICHTING RADBOUD UNIVERSITEIT
Netherlands, Nijmegen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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