CORDIS Project
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This research aims to uncover the molecular mechanisms regulating L-cells in the intestine, which produce hormones that control glucose metabolism and body weight. It focuses on identifying transcription factors that influence hormone expression and release.
L-cells in the intestinal epithelium are specialized enteroendocrine cells which secrete several peptide hormones after a meal, including glucagon-like peptide 1 (GLP1), oxyntomodulin (OXM) and peptide tyrosine tyrosine (PYY).
These hormones are key regulators of glucose metabolism and body weight, by stimulating insulin release by pancreatic beta cells, slowing down gastric emptying and by acting on brain areas involved in body weight control.
Although all three of these hormones are at least i…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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