CORDIS Project
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This project investigates the mechanism of positive supercoiling in DNA by the enzyme reverse gyrase. By employing single molecule techniques, the research aims to reveal how the enzyme interacts with DNA and undergoes conformational changes during the supercoiling process, enhancing our understanding of DNA dynamics.
Reverse gyrase is the only topoisomerase known till date that can introduce positive supercoils into DNA.
From the biochemical and biophysical evidence gained so far, it is known that the enzyme only relaxes negatively supercoiled DNA, and introduces positive supercoils in presence of ATP at high temperatures.
The exact picture of conformational changes and inter-domain cross talk during the positive supercoiling reaction has not yet been captured biophysically.
The proposed work is aimed at gai…
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